王思雨，男
南京邮电大学高层次（第四层次）引进人才
联系方式
办公地点：南京邮电大学仙林校区材料学科楼154
Email: iamsiyuwang@njupt.edu.cn
工作经历
2026.01-至今南京邮电大学材料科学与工程学院教授
2022.11-2025.12 美国西奈山伊坎医学院免疫学与免疫治疗博士后（合作导师：Yizhou Dong）
2022.10-2022.11 美国俄亥俄州立大学药学博士后（合作导师：Yizhou Dong）
主要学术成绩
近年来，本人围绕智能生物材料设计及其在脑部疾病治疗中的应用开展研究，重点在脑靶向药物递送系统构建、跨血脑屏障递送机制及核酸药物精准递送等方面取得了系统性进展。以第一作者或共同第一作者身份在Nature Reviews Drug Discovery、Nature Materials、Nature Biotechnology、Science Advances、PNAS等期刊发表论文13篇，总发表论文34篇；申请发明专利8件，其中获授权6件，含国际专利2件。曾获“江苏省优秀博士学位论文（2023）”“全国博士生学术论坛百强（2021）”等荣誉。
当前研究方向
智能生物材料在脑部疾病精准治疗中的设计与应用，包括智能生物材料设计与构建、跨血脑屏障递送机制解析及核酸药物精准递送与治疗。
代表性成果
(1) Siyu Wang, Drew Weissman*, Yizhou Dong*. RNA Chemistry and Therapeutics. Nature Reviews Drug Discovery, 2025, 24, 828–851.
(2) Chang Wang#, Siyu Wang#, Yonger Xue, Yichen Zhong, Haoyuan Li, Xucheng Hou, Diana D. Kang, Zhengwei Liu, Meng Tian, Leiming Wang, Dinglingge Cao, Yang Yu, Jayce Liu, Xiaolin Cheng, Tamara Markovic, Alice Hashemi, Brian Kopell, Alexander Charney, Eric Nestler*, Yizhou Dong*. Intravenous administration of blood–brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system. Nature Biotechnology, 2025, 43, 1783–1789.
(3) Jue Yin#, Siyu Wang#, Jiahui Wang#, Yewei Zhang, Chunhai Fan, Jie Chao*, Yu Gao*, Lianhui Wang*. An intelligent DNA nanodevice for precision thrombolysis,Nature Materials, 2024,23, 854-862.
(4) Yonger Xue#, Xucheng Hou#, Siyu Wang#, Yuebao Zhang, Yichen Zhong, Diana D. Kang, Chang Wang, Haoyuan Li, Changyue Yu, Zhengwei Liu, Meng Tian, Dinglingge Cao, Yaying Zheng, Binbin Deng, Pauline Hamon, Miriam Merad, Yizhou Dong. Pulmonary delivery of peptibody mRNA using anti-inflammatory lipids to treat multidrug-resistant bacterial pneumonia. Nature Biotechnology, 2025, 10.1038/s41587-025-02928-x.
(5) Siyu Wang#, Yuebao Zhang#, Yichen Zhong#, Yonger Xue, Zhengwei Liu, Chang Wang, Diana D. Kang, Haoyuan Li, Xucheng Hou, Meng Tian, Dinglingge Cao, Leiming Wang, Kaiyuan Guo, Binbin Deng, David W. McComb, Miriam Merad, Brian D. Brown, Yizhou Dong*. Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle–mRNA formulation. Proceedings of the National Academy of Sciences, 2024，121, e2322935121.
(6) Siyu Wang, Xixi Guo, Weijun Xiu, Yang Liu, Lili Ren, Huaxin Xiao, Fang Yang, Yu Gao*, Chenjie Xu, Lianhui Wang*. Accelerating thrombolysis using a precision and clot-penetrating drug delivery strategy by nanoparticle-shelled microbubbles.Science Advances, 2020, 6, eaaz8204.