鲍碧清

联系方式
办公地点：南京市文苑路9号南京邮电大学仙林校区教五楼#310

 Email：iambqbao@njupt.edu.cn  
 研究方向
       研究工作主要涉及光电功能材料的设计和性能研究；基于光电功能材料和纳米生物材料的新型化学生物检测体系；发展用于生物医学研究和生物分子检测的高灵敏度化学生物分析体系等。
主要研究项目
      1. 国家自然科学基金面上项目“基于近红外二区成像的诊疗一体化有机纳米试剂及其在肿瘤联合治疗中的应用研究”，编号21875113，2019年1月- 2022年12月，项目负责人。

2. 国家自然科学基金面上项目“新型POSS基纳米生物探针构建及基于微流控技术的肿瘤标志物多分子检测研究”编号21574069，2016年1月- 2019年12月，项目负责人。
      3. 国家自然科学基金青年基金“基于共轭聚合物纳米生物探针的微流控芯片构建及其在肿瘤标志物检测中的应用”编号21204038，2013年1月- 2015年12月，项目负责人，结题。
      4. 江苏省自然科学基金面上项目“多功能有机共轭分子杂化发光材料的制备及生物检测研究”，编号BK20151503，2015年7月-2018年6月，项目负责人。
      5. 江苏省高校自然科学研究面上项目“水溶性共轭高分子对毒性金属离子的荧光比色法识别”，编号11KJB150010，2011年9月-2013年12月，项目负责人。
      6. 南京邮电大学引进人才启动金项目“DNA-共轭高分子复合荧光材料的生物传感研究”，编号NY211023，2011年10月-2013年12月，项目负责人。
      7. 南京邮电大学国自基金孵育项目“新型生物功能化水溶性共轭高分子的设计及其在核酸传感器中的应用”，编号NY211123，2012年1月-2012年12月，项目负责人。
主要学术成绩
          长期从事导电高分子光电功能材料的设计，制备和应用研究。主要成果有：开发了系列性能优良导电高分子传感材料，系统研究了导电高分子纳米生物材料的制备方法，并初步探索了导电高分子及其纳米材料在分析检测、生物医学领域的应用。相关科研成果已发表在Theranostics、Advanced Science、Chemical Communications、ACS Applied   Materials & Interfaces、Soft Materials等国际学术期刊上。

代表性著作          

1. Biqing Bao, Peng Su, Kewei Song, Yunxiao   Cui, Xue Zhai, Yu Xu, Junle Liu*, and Lianhui Wang*, A Smart   “Sense-and-Treat” Nanoplatform Based on Semiconducting Polymer Nanoparticles   for Precise Photothermal-Photodynamic Combined Therapy, Biomacromolecules,   2021, 22, 3, 1137-1146.

2.   Jia Chen,   Yunxiao Cui,   Kewei Song,   Tianqi Liu,   Luyao Zhou,   Biqing Bao,*   Ruibing Wang ^b  and  Lianhui Wang, Self-Assembly of Hybrid Photosensitizer for   Synergistically Enhanced Photodynamic/Photothermal Therapy, Biomaterials   Science, 2021, 9, 2115-2123.

3.  Biqing Bao, Xue Zhai, Tianqi Liu, Peng Su,   Luyao Zhou, Yu Xu, Bingbing Gu and Lianhui Wang*, Cubic POSS engineering of   photosensitizer-doped semiconducting polymer nanoparticles for enhanced   fluorescence imaging and amplified photodynamic therapy, Polymer Chemistry, 2020,11, 7035-7041.

4.  Yu Xu, Xue Zhai, Peng Su, Tianqi   Liu, Luyao Zhou, Jingjing Zhang, Biqing   Bao* and Lianhui Wang*, Highly stable semiconducting polymer   nanoparticles for multi-responsive chemo/photothermal combined cancer therapy,   Theranostics, 2020.

5.  Biqing Bao, Li Tong, Yu Xu,   Jingjing Zhang, Xue Zhai, Peng Su, Lixing Weng* and Lianhui Wang*,   Mussel-inspired functionalization of semiconducting polymer nanoparticles for   amplified photoacoustic imaging and photothermal therapy, Nanoscale, 2019, 11, 14727-14733.

6.  Biqing Bao, Peng Su,   Zhenyuan Yang, Xue Zhai, Jingjing Zhang, Yu Xu, Yunfei Liu, Bingbing Gu, and   Lianhui Wang*, Highly Stable Core-Shell Structured Semiconducting Polymer   Nanoparticles for FRET-Based Intracellular pH Imaging, Advanced Healthcare Materials,2019, 10.1002/adhm.201900255.

7. Yu Xu, Jia Chen, Li Tong, Peng Su, Yunfei Liu,   Bingbing Gu, Biqing Bao,*   and Lianhui Wang*, pH/NIR-responsive semiconducting polymer nanoparticles for   highly effective photoacoustic image guided chemo-photothermal synergistic   therapy, Journal of Controlled Release,   2019, 293, 94-103.

8.  Biqing Bao, Zhenyuan Yang,   Yunfei Liu, Yu Xu, Bingbing Gu, Jia Chen, Peng Su, Li Tong, and Lianhui Wang,   Two-Photon Semiconducting Polymer Nanoparticles as a New Platform for Imaging   of Intracellular pH Variation, Biosensor   and Bioelectronics, (DOI: 10.1016/j.bios.2018.10.027).

9. Jia Chen, Jingyang Shan,Yu Xu, Peng Su, Li   Tong, Lihui Yuwen, Lixing Weng, Biqing   Bao,* and Lianhui Wang*, Polyhedral Oligomeric Silsesquioxane   (POSS)-Based Cationic Conjugated Oligoelectrolyte/Porphyrin for Efficient   Energy Transfer and Multiamplified Antimicrobial Activity, ACS Applied Materials & Interfaces,   2018, 10, 34455−34463.

10. Biqing Bao, Peng Su, Jin   Zhu, Jia Chen, Yu Xu, Bingbing Gu, Yunfei Liu, and Lianhui Wang*, Rapid   aptasensor capable of simply detect tumor markers based on conjugated   polyelectrolytes, Talanta,   2018,190, 204–209.

11. Biqing Bao, Yanrui Pan,   Bingbing Gu, Jia Chen, Yu Xu, Peng Su, Yunfei Liu, Li Tong and Lianhui Wang*,   Highly sensitive detection of nucleic acids using a cascade amplification   strategy based on exonuclease III-assisted target recycling and conjugated   polyelectrolytes, Analyst, 2018,   143, 4267-4272.

12. Jia Chen, Yu Xu, Yu Gao, Dongliang Yang, Fei   Wang, Lei Zhang, Biqing Bao,*   and Lianhui Wang*, Nanoscale Organic−Inorganic Hybrid Photosensitizers for   Highly Effective Photodynamic Cancer Therapy, ACS Applied Materials & Interfaces, 2018, 10, 248−255.

13.  Biqing Bao, Jin Zhu, Lina   Gong, Jia Chen, Yanrui Pan and Lianhui Wang, Sensitive DNA detection using   cascade amplification strategy based on conjugated polyelectrolytes and   hybridization chain reaction. RSC   Advances, 2017, 7, 3528-3533.

14. Dongliang Yang, Fei Li, Zhimin Luo, Biqing Bao*, Yanling Hu,   Lixing Weng, Yixiang Cheng, and Lianhui Wang, Conjugated Polymer   Nanoparticles with Aggregation Induced Emission Characteristics for   Intracellular Fe³⁺ Sensing. Journal   of Polymer Science, Part A: Polymer Chemistry, 2016, 54, 1686-1693.

15.  Biqing Bao, Mingfeng Ma,   Huafeng Zai, Lei Zhang, Nina Fu, Wei Huang and Lianhui Wang, Conjugated   Polymer Nanoparticles for Label-Free and Bioconjugate-Recognized DNA Sensing   in Serum. Advanced Science, (DOI:   10.1002/advs.201400009).

16. Biqing Bao, Mingfeng Ma,   Jia Chen, Lihui Yuwen, Lixing Weng, Quli Fan, Wei Huang and Lianhui Wang,   Facile Preparation of Multicolor Polymer Nanoparticle Bioconjugates with   Specific Biorecognition. ACS Applied   Materials & Interfaces, 2014, 6, 11129-11135.

17. Biqing Bao, Nanjiao Tao,   Dongliang Yang, Lihui Yuwen, Lixing Weng, Quli Fan,Wei Huang and Lianhui   Wang, A Controllable Approach to Development of Multi-Spectral Conjugated   Polymer Nanoparticles with Increased Emission for Cell Imaging. Chemical Communication, 2013, 49,   10623-10625.