高宇

发布者:材料科学与工程学院、信息科学与纳米技术研究院 发布时间:2017-06-16浏览次数:8244



高宇

男,山东济南人

南京邮电大学材料科学与工程学院/信息材料与纳米技术研究院   副教授


联系方式

办公地点:南京市文苑路9号南京邮电大学仙林校区教5-211

Emailiamygao@njupt.edu.cn

个人简历

2004年获山东大学化学与化工学院化学专业学士学位;

2006年至2007年于厦门大学固体表面物理化学国家重点实验室交流;

2008年获中南大学化学化工学院分析化学专业硕士学位;

2012年获中国科学院生态环境研究中心(环境化学与生态毒理学国家重点实验室)环境科学专业博士学位;

201211月至201512月于新加坡南洋理工大学化学与生物医学工程学院从事博士后研究;

201512月加盟南京邮电大学。

研究方向

微纳米技术在生物医学领域的应用,包括:智能微纳材料在心血管和肿瘤等重大疾病中的应用;超声造影及药物递送系统的设计与应用;智能响应生物材料在组织工程中的应用。

主要研究项目

1.国家自然科学基金青年基金项目:“用于可控纳米粒子递送的功能化磁性微泡的设计与其在治疗血管阻塞的应用”,项目编号8160160820171-201912月,项目负责人。

2. 江苏省前沿引领技术基础研究专项:“面向生物医药的智能微纳材料精准设计及可控组装技术”,项目编号BK20212012202110-20249月,参与。

3.江苏省科技厅重点研发计划-社会发展临床前沿技术:基于微针技术的病理性瘢痕治疗项目编号BE201677020167-20196月,参与。 

4.江苏省自然科学基金青年基金项目:功能化磁性微泡的设计与其在治疗血管再狭窄中的应用,项目编号BK2016091920167-20196月,项目负责人。

5.公安部合作项目:“麻醉药物及持久性有机污染物的胚胎干细胞神经毒理研究”,20208-20227月,项目负责人。 

6.江苏省教育厅省高校自然科学研究面上项目:“可植入纳米复合材料的制备与其在肿瘤治疗中的应用研究项目编号16KJB31000820167-20186月,项目负责人。 

7.中国科学院生态环境研究中心-环境化学与生态毒理学国家重点实验室开放课题:用于实时监测持久性有毒污染物细胞毒性的纳米传感器的设计与应用项目编号KF2016-0520171-201812月,项目负责人。

8.南京邮电大学引进人才科研启动基金项目:基于磁性微泡纳米药物递送系统的设计与应用项目编号NY21602420167-20196月,项目负责人。

主要学术成绩

围绕微纳米技术的生物医学应用,聚焦微纳气泡的高性能多功能化及其在心血管、肿瘤和再生医学中的应用开展了系统性的研究,相关工作(第一作者或通讯作者)发表在Science Advances, Chemical Society Reviews, NPG Asia Materials等著名学术期刊上。 

主要学术任职

1Materials Technology期刊编委(Editorial board;

2Frontiers in Bioengineering and Biotechnology期刊客座副主编(Guest associate editor;

3)中国超声医学工程学会超声治疗及生物效应专业委员会委员;

4)江苏省生物医学工程协会体外诊断技术专业委员会委员。

代表性著作

(1) Yu Gao, Yi Liu, Chenjie Xu*, Magnetic Nanoparticles for Biomedical Applications: From Diagnosis to Treatment to RegenerationEngineering in Translational Medicine, Weibo Cai, Springer-Verlag London, pp 567-583, 2014.

代表性论文(一作及通讯)

1. Shengpei Shao, Siyu Wang, Lili Ren, Jiahui Wang, Xinmeng Chen, Hequn Pi, Yongjing Sun, Chen Dong, Lixing Weng, Yu Gao* and Lianhui Wang*, Layer-by-Layer assembly of lipid nanobubbles on microneedles for ultrasound-assisted transdermal drug delivery. ACS Applied Bio Materials, 2022, 5, 562-569

2.  2.Yu Gao#, Jiahui Wang#, Hao Han#, Huaxin Xiao, Wei-kui Jin, Siyu Wang, Shengpei Shao, Zhixuan Wang, Wenjing Yang, Lianhui Wang, Lixing Weng*, A nanoparticle-containing polycaprolactone implant for combating post-resection breast cancer recurrence. Nanoscale, 2021, 13, 14417-14425

3.  3.Siyu Wang, Xixi Guo, Weijun Xiu, Yang Liu, Lili Ren, Huaxin Xiao, Fang Yang, Yu Gao*, Chenjie Xu, Lianhui Wang*, Accelerating thrombolysis using a precision and clot-penetrating drug delivery strategy by nanoparticle-shelled microbubbles. Science Advances, 2020, 6, eaaz8204

4.   4. Siyu Wang, Xixi Guo, Lili Ren, Bo Wang, Lixin Hou, Hao Zhou, Qinchang Gao, Yu Gao*, Lianhui Wang*, Targeting and deep-penetrating delivery strategy for stented coronary artery by magnetic guidance and ultrasound stimulation. Ultrasonics Sonochemistry, 2020, 67, 105188.

5.   5.Ying Yin#, Siyu Wang#, Danni Hu, Jingyao Cai, Fubin Chen, Bo Wang, Yu Gao*, Magnetic-, acoustic-, and optical-triple-responsive microbubbles for magnetic hyperthermia and pothotothermal combination cancer therapy. Journal of Visualized Experiments, 2020, 159, e61208.

6.   6.  Yu Gao#, Xixi Guo#, Siyu Wang, Fubin Chen, Xiaomin Ren, Huaxin Xiao, Lianhui Wang*, Perfluorooctane sulfonate enhances mRNA expression of PPARγ and ap2 in human mesenchymal stem cells monitored by long-retained intracellular nanosensor. Environmental Pollution, 2020, 263, 114571.

7.   7.  Yu Gao*, Yanbo Pei* and Ming-Yuan Wei*, Editorial: Nanomedicine for deep-tissue high-resolution bio-imaging and non-invasive therapy. Frontiers in Bioengineering and Biotechnology, 2020, 8, 1002

8.     8.Yu Gao, Yiyuan Han , Mingyue Cui, Hong Liang Tey, Lian-Hui Wang*, Chenjie Xu*, ZnO nanoparticles as an antimicrobial tissue adhesive for skin wound closure. Journal of Materials Chemistry B, 2017, 5, 4535-4541 (themed issue-Emerging Investigators 2017)

9.     9.Yu Gao#, Ammar Mansoor Hassanbhai#, Jing Lim#, Lianhui Wang*, Chenjie Xu*, Fabrication of a silver octahedral nanoparticle-containing polycaprolactone nanocomposite for antibacterial bone scaffolds. RSC Advances, 2017, 7, 10051-10056

10.  10.Yu Gao#, Chon U Chan#, Qiushi Gu, Xudong Lin, Wencong Zhang, David Chen Loong Yeo, Astrid Marlies Alsema, Manish Arora, Mark Seow Khoon Chong, Peng Shi, Claus-Dieter Ohl*, Chenjie Xu*, Controlled Nanoparticle Release from Stable Magnetic Microbubble Oscillations, NPG Asia Materials, 2016, 8, e260

11.  11.Yu Gao, Chenjie Xu*, Lianhui Wang*, Non-invasive monitoring of the osteogenic differentiation of human mesenchymal stem cells on a polycaprolactone scaffold using Raman imaging. RSC Advances, 2016, 6, 61771-61776

12. 12. Yu Gao, Jing Lim, David Yeo, Shanshan Liao, Malin Lans, Yaqi Wang, Swee Hin Teoh, BeeTin Goh, Chenjie Xu*, A selective and Purification-free Strategy for Labeling Adherent Cell with Inorganic Nanoparticles. ACS Applied Materials & Interfaces, 2016, 8 (10), 6336–6343

13.  13.Yu Gao#, Jing Lim#, Yiyuan Han, Lifeng Wang, Mark Seow Khoon Chong, Swee-Hin Teoh, Chenjie Xu*, Cryomilling for the Fabrication of Doxorubicin-containing Silica-nanoparticle/polycaprolactone Nanocomposite Films, Nanoscale, 2016, 8, 2568-2574

14.  14.Yu Gao, Jing Lim, Swee-Hin Teoh, Chenjie Xu*. Emerging Translational Research on Magnetic Nanoparticles for Regenerative Medicine. Chemical Society Reviews, 2015, 44, 6306-6329

15. 15. Yu Gao, Yaqi Wang, Afu Fu, Wei Shi, David Yeo, Kathy Qian Luo, Hooisweng Ow, Chenjie Xu*. Tracking Mesenchymal Stem Cell Tumor-homing Using Fluorescent Silica Nanoparticles. Journal of Materials Chemistry B, 2015, 3, 1245-1253

16. 16. Yu Gao#, Khay Ming Tan#, Yihan Li, Kyung Taeck Minn, Astrid Marlies Alsema, Chenjie Xu*. Characterization of Titanium Dioxide Nanoparticles on Porcine Skin by Raman Microscopy. Analytical Letters, 2015, 48(15), 2391-2399

17.  17.Yu Gao, Yan Cui, Jerry K Y Chan, Chenjie Xu*. Stem Cell Tracking with Optically Active Nanoparticles. American Journal of Nuclear Medicine and Molecular Imaging, 2013, 3(3):232-246

18.  18.Yu Gao, Xinxin Li, Liang-Hong Guo*. Assessment of Estrogenic Activity of Perfluoroalkyl Acids Based on Ligand-induced Conformation State of Human Estrogen Receptor. Environmental Science & Technology, 2013, 47 (1):634–641

19.  19.Yu Gao, Xinxin Li, Liang-Hong Guo*. Development of a Label-free Competitive Ligand Binding Assay with Human Serum Albumin on Molecularly Engineered Surface Plasmon Resonance Sensor Chip. Analytical Methods, 2012, 4(11):3718-3723

20.  20.高宇,崔颜,向娟*,任斌*,脱金属硫蛋白吸附在粗糙金表面的表面增强拉曼光谱,光散射学报2008, 20(2):173-177

专利申请/授权

1.     1.一种用于光热-免疫联合治疗的抗肿瘤自愈合水凝胶的制备方法,申请号:202110312008.1

2.     2.一种用于递送蛋白药物的磁性血小板复合物的制备方法,申请号:202010815820.1

3.     3.一种荧光纳米传感器标记的拟胚体的制备方法及毒性筛查应用,申请号:202010044899.2

4.     4.一种用于化合物毒性筛查的细胞内传感器、制备方法以及使用方法,申请号:201910413297.7

5.    5. 一种载药磁性微泡及其制备方法和应用,专利号:    ZL201811293218.5

6.     6.一种用于抑制术后肿瘤复发的纳米复合材料的制备方法和应用,专利号:ZL201811293699.X