张磊

时间:2015-09-09   浏览:5713

 

     男,汉族,河南郑州人。
     南京邮电大学信息材料与纳米技术研究院/材料科学与工程学院
     教授、博士生导师。               

               

  

联系方式                

        南京市文苑路9号 南京邮电大学仙林校区教五楼422室

        Email:iamlzhang@njupt.edu.cn

                 
个人简历
        1999-2003 东南大学 化学化工学院 本科;
        2003-2005 黎明化工研究院 助理工程师;
        2005-2008 获南京工业大学 理学院 应用化学 硕士;
        2008-2011 华东理工大学 化学与分子工程学院 分析化学 博士;
        2011-至今 南京邮电大学 材料科学与工程学院 教授、博士生导师。
                 其中 2016-2017 美国 斯坦福大学 医学院 访问学者   
 

             
研究方向

       以等离子激元纳米材料的设计、组装及生物传感在生物医学领域应用为目标,开展了一系列单颗粒等离子激元生物传感研究。并长期围绕“形貌调控、可控自组装、表面功能化与等离子激元光学性能的相互关系”这一系列关键科学问题开展了系统性和创新性研究。

         

        1. 等离子激元结构设计、合成及应用;
        2. 单颗粒SERS化学增强机理及生物应用;
        3. 单颗粒表面等离子共振散射光谱生物传感机制探索及应用;
        4. 纳米颗粒光热/光声在精准医疗中的应用。
     
                 

主要研究项目                   

       1. 国家自然科学基金面上项目,DNA折纸术用于纳米等离子激元界面调控及光学逻辑应用,62075103,2021.1-2024.12,60万元,主持,在研;
       2. 江苏省自然科学基金面上项目,基于SPR/SERS联用的肿瘤早期标志物生物传感研究,BK20211271,2021.7-2024.6,10万元,主持,在研;
  3. 国家自然科学基金面上项目,基于耦合增强卫星结构的纳米等离子激元miRNA生物传感器,61571239,2016.1-2019.12,60万元,主持,结题;
       4. 国家自然科学基金,青年科学基金项目,纳米等离子激元光学探针监测药物载体的智能释放研究,61205195,2013.01-2015.12,29万元,主持,结题;
       5. 东南大学生物电子学国家重点实验室开放研究基金,基于纳米等离子体光谱技术的肺癌标志物生物传感器研究,BJ211029,2011.12-2013.12,5万元,主持,结题;
  6. 教育部高等学校博士学科点专项科研基金新教师类,等离子激元探针监测纳米载体的可控药物释放,20123223120011,2013.1-2015.12,4万元,主持,结题;
  7. 江苏省高校自然科学基础研究项目面上项目,肿瘤标志物microRNA的纳米等离子激元光学探针研究,12KJB150018,2012.09-2014.12,3万元,主持,结题。

 

主要学术成绩

      先后以第一或通讯作者在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、ACS Nano、Small、Chem. Commun.等国际顶级期刊发表高水平SCI论文60余篇,累计被引用4600余次,个人H-index为30;授权发明专利8项;参与撰写学术著作两部。

                
代表性著作‍‍‍‍ 

       1) Zhang L., Zhuang W., Yuan Y., Shen J., Shi W., Liu G., Wu W., Zhang Q., Shao G., Mei Q., Fan Q., Novel Glutathione Activated Smart Probe for Photoacoustic Imaging, Photothermal Therapy, and Safe Postsurgery Treatment. ACS Applied Materials & Interfaces, 2022, 14 (21), 24174-24186.

     2) Feng N., Zhang L., Shen J., Hu Y., Wu W., Kouadio Fodjo E., Chen S., Huang W., Wang L., SERS Molecular-Ruler Based DNA Aptamer Single-Molecule and Its Application to Multi-Level Optical Storage. Chemical Engineering Journal, 2022, 433, 133666.

  3) Feng N., Shen J., Li C., Zhao Q., Fodjo E.K., Zhang L., Chen S., Fan Q., Wang L., Tetrahedral DNA-Directed Core-Satellite Assembly as SERS Sensor for Mercury Ions at the Single-Particle Level. Analyst, 2022, 147 (9), 1866-1872.

  4) Feng N., Li C., Shen J., Hu Y., Fodjo E.K., Zhang L., Chen S., Fan Q., Wang L., 1,4-Benzenedithiol-Bridged Nanogap-Based Individual Particle Surface-Enhanced Raman Spectroscopy Mechanical Probe for Revealing the Endocytic Force. ACS Nano, 2022, 16 (4), 6605–6614.

  5) Feng N., Shen J.j., Chen Y., Li C., Hu Y.l., Zhang L., Chen S.f., Fan Q.l., Huang W., Wang L.h., Multifunctional Shape-Dependent Plasmonic Nanoprobe by Enzymatic Etching of Single Gold Triangular Nanoplate. Nano Research, 2020, 13 (12), 3364-3370.

  6) Shen J., Zhang L., Liu L., Wang B., Bai J., Shen C., Chen Y., Fan Q., Chen S., Wu W., Feng X., Wang L., Huang W., Revealing Lectin–Sugar Interactions with a Single Au@Ag Nanocube. ACS Applied Materials & Interfaces, 2019, 11 (43), 40944-40950.

  7) Zhang Y., Shuai Z., Zhou H., Liu B., Zhang Y., Zhang L., Chen S., Chao J., Weng L., Fan Q., Fan C., Huang W., Wang L., Single-Molecule Analysis of microRNA and Logic Operations Using a Smart Plasmonic Nanobiosensor. Journal of the American Chemical Society, 2018, 140 (11), 3988-3993.

  8) Tian Y., Shuai Z., Shen J., Zhang L., Chen S., Song C., Zhao B., Fan Q., Wang L., Plasmonic Heterodimers with Binding Site-Dependent Hot Spot for Surface-Enhanced Raman Scattering. Small, 2018, 14 (24), e1800669.

  9) Zhang L., Wang J., Zhang J., Liu Y., Wu L., Shen J., Zhang Y., Hu Y., Fan Q., Huang W., Wang L., Individual Au-Nanocube Based Plasmonic Nanoprobe for Cancer Relevant Microrna Biomarker Detection. ACS Sensors, 2017, 2 (10), 1435-1440.

  10) Tian Y., Zhang L., Shen J., Wu L., He H., Ma D.-L., Leung C.-H., Wu W., Fan Q., Huang W., Wang L., An Individual Nanocube-Based Plasmonic Biosensor for Real-Time Monitoring the Structural Switch of the Telomeric G-Quadruplex. Small, 2016, 12 (21), 2913-2920.

  11) Zhang L., Zhang Y., Hu Y., Fan Q., Yang W.J., Li A., Li S., Huang W., Wang L.-H., Refractive Index Dependent Real-Time Plasmonic Nanoprobes on Single Silver Nanocube for Ultrasensitive Detection of the Lung Cancer-Associated Mirnas. Chemical Communications, 2015, 51 (2), 294-297.

  12) Hu Y., Zhang L., Zhang Y., Wang B., Wang Y., Fan Q., Huang W., Wang L., Plasmonic Nanobiosensor Based on Hairpin DNA for Detection of Trace Oligonucleotides Biomarker in Cancers. ACS Applied Materials & Interfaces, 2015, 7 (4), 2459-2466.

  13) Zhang L., Li Y., Li D.-W., Jing C., Chen X., Lv M., Huang Q., Long Y.-T., Willner I., Single Gold Nanoparticles as Real-Time Optical Probes for the Detection of NADH-Dependent Intracellular Metabolic Enzymatic Pathways. Angewandte Chemie International Edition, 2011, 50 (30), 6789-6792.

  14) Zhang L., Li D.-W., Song W., Shi L., Li Y., Long Y.-T., High Sensitive on-Site Cadmium Sensor Based on AuNPs Amalgam Modified Screen-Printed Carbon Electrodes. IEEE Sensors Journal, 2010, 10 (10), 1583-1588.

  15) Zhang L., Tian D.-B., Zhu J.-J., Third Generation Biosensor Based on Myoglobin-TiO2/MWCNTs Modified Glassy Carbon Electrode. Chinese Chemical Letters, 2008, 19 (8), 965-968.