美国佐治亚理工学院柯勇刚教授学术报告通知

发布者:材料科学与工程学院、信息科学与纳米技术研究院 发布时间:2019-06-20浏览次数:58

报告题目DNA as a programmable nanomaterial

报 告 人柯勇刚教授

单   位美国佐治亚理工学院

报告时间:2019年620日下午3:00

报告地点:材料学科楼4楼413会议室

 


报告摘要:

A key challenge in nanotechnology is to design and fabricate nanostructures and nanodevices, which can be used as general platforms for basic science research (e.g. material sciences, structural biology, molecular biology, etc.), and for practical applications. Owing largely to its programmable design strategies, nucleic acids self-assembly, and in particular DNA self-assembly, has emerged as a powerful approach in programming self-assembly of custom-designed intricate nanostructures. 


  The core mission of our lab (ke-lab.gatech.edu) is to develop novel bottom-up self-assembly strategies to fully demonstrate the potential of DNA as a programable nanomaterial. Our most recent work focuses on making massive/complex static DNA nanostructures and dynamic DNA devices. In this talk, I will discuss how we can construct fully addressable GDa nanostructures from modular DNA components called “DNA bricks”, and dynamic DNA nanomachines that can perform a range of controlled motions at nanoscale. Beyond sophisticated nanostructures and nanomachinces, DNA nanotechnology has found increasing capabilities in many applications, such as fabrication of functional materials at nanoscale precision. As examples of DNA-based applications, I will also present some of our most recent works on DNA-templated self-assembly of nanoparticles, and on DNA-based nanoscale drug delivery systems.

Reference:

1. Ong, L. L.; Hanikel, N.; Yaghi, O. K.; Grun, C.; Strauss, M. T.; Bron, P.; Lai-Kee-Him, J.; Schueder, F.; Wang, B.; Wang, P.; Kishi, J. Y.; Myhrvold, C.; Zhu, A.; Jungmann, R.; Bellot, G.*; Ke, Y.*; Yin, P.*, Nature, 2017, 552(7683), 72.

2. Iinuma, R.; Ke, Y.; Jungmann, R.; Schlichthaerle, T.; Woehrstein, J. B.; Yin, P.*, Science, 2014, 344(6179), 65-69.

3. Ke, Y.*; Ong, L. L.; Sun, W.; Song, J.; Dong, M.; Shih, W. M.; Yin, P.*, Nature Chemistry, 2014, 6(11), 994-1002.

4. Wang, D.; Song, J.*; Wang, P.; Pan, V.; Zhang, Y.; Cui, D.*; Ke, Y.*, Nature Protocols, 2018, 13(10), 2312-2329.

5. Ke, Y.*; Meyer, T.; Shih, W. M.; Bellot, G.*, Nature Communications, 2016, 7.

 

报告人简介

 柯勇刚,1999年毕业于北京大学,2009年在亚利桑那州立大学获得博士学位,2009-2014年在哈佛大学Dana-Farber癌症研究所从事博士后研究,2014年至今在佐治亚理工学院生物医学工程系任助理教授。在复杂DNA纳米结构的设计与组装和动态DNA装置调控变构作用及其应用研究方面开展了大量的研究工作,以第一作者或通讯作者在 ScienceNatureNature ChemistryNature NanotechnologyNature CommunicationsJournal of the American Chemical SocietyChemical ScienceNano LettersACS NanoSmallCurrent Opinions in Structural Biology等国际一流期刊发表论文近50篇,SCI论文总引用次数超过3300余次。